Enzyme Therapy in Genetic Diseases 2

chromosomes, and the sections are divided into structural variations and anomalies, numerical variations and anomalies, double aneuploidies, chromosome breakage syndromes, and a small list of mapping data of loci assigned to chromosomes. A short appendix outlines the clinical features of the major autosomal and sex chromosome abnormalities. This book is a veritable gold mine of information about all of the known chromosomal variations in the world. It will not serve the general physician who wishes to know clinical information about chromosome abnormalities. It has only a few photographs in the small appendix. But for workers in clinical genetics and cytogenetics the work will be invaluable as a reference tool both as a quick reference when evaluating a particular karyotype of an unusual nature and as an entree to the literature of this rapidly growing subject. The volume will not be particularly helpful to house officers and students but belongs on the library shelf for reference.